Version 4.3.02 release on Aug 25th 2011. New version
of TTD provides Quantitative
Structure-Activity Relationship (QSAR) models
Validation Information for TTD drug target.
Target Agents Data with structure and potency
Combinations and Nature-derived
Drugs together with drug species origin data
are also included.
to provide information about the known and explored therapeutic
protein and nucleic acid targets, the targeted disease, pathway
information and the corresponding drugs directed at each of these
targets. Also included in this database are links to relevant
databases containing information about target function, sequence,
3D structure, ligand binding properties, enzyme nomenclature and
drug structure, therapeutic class, clinical development status.
All information provided are fully referenced.
of this database
database currently contains 2,025
targets, including 364
successful, 286 clinical
trial, 44 discontinued
and 1,331 research targets,
drugs, including 1,540
approved, 1,423 clinical
trial, 14,853 experimental
drugs and 3,681
multi-target agents (14,170
small molecules and 652
antisense drugs with available strucuture or oligonucleotide sequence).
and drugs in this database cover 61
protein biochemical class and 140
drug therapeutic classes respectively.
to cite our database
Zhu F, Shi Z, Qin C, Tao L, Liu X, Xu F, Zhang L, Song Y, Liu XH, Zhang JX, Han BC, Zhang P, Chen YZ. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 40(D1): D1128-1136, 2012. PubMed.
X, Ji ZL, Chen YZ. TTD: Therapeutic Target Database. Nucleic
Acids Res. 30(1):412-415,
Han BC, Pankaj Kumar, Liu XH, Ma XH, Wei XN, Huang L, Guo YF,
Han LY, Zheng CJ, Chen YZ. Update of TTD: Therapeutic Target Database.
Acids Res. 38(suppl
1):D787-91, 2010. PubMed
since 2002 .........
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Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore